Metabolic Pathways

Biological Control Systems

Topics:
1. Regulation of Blood Glucose Levels.
Publications:
1. W. Liu and Fusheng Tang, A New Hybrid Distributed Parameter Control Model for
  the Regulatory Network of Blood Glucose, submitted, 2007.
2. Luis Jimenez, Christopher Pickens, and Weijiu Liu, Mathematical Determination of Competitive Feedback Inhibition Rates in Branched Metabolic Pathways, submitted, 2006.
3. Ramesh Garimella, Uma Garimella, and Weijiu Liu, A Theoretic Control Approach in a Signal-controlled Metabolic Pathway, submitted, 2006.
Research Students:

Jing Voon Chen (Fall 2008)

Luis R. Suazo (Summer 2008)

Eric Sellers (Fall 2007, Spring 2008)

Christopher J. Willette (Fall 2007, Spring 2008)

CingChun Hsin (Summer and Fall 2007, Spring 2008)

Leonardo Challenger (Spring 2007)

Oumarou Tahirou (Spring 2007)

Joel Terwilliger (Spring 2007)

Luis Jimenez (Summer 2006).

Christopher Pickens (Summer 2006).

Collaborators:
1. Professor Ramesh Garimella (Math, UCA).
2. Professor Uma Garimella (Biology, UCA).
3. Professor Fusheng Tang (Biology, UALR).
Useful Links:
1. http://www.endocrineweb.com/insulin.html

Pathways from inosinic acid to GMA and AMP.

Purine metabolic pathway.

KEGG PATHWAY Database
KEGG Regulatory Pathways -- a collection of graphical pathway maps, ortholog
group tables, and molecular...
www.genome.jp/kegg/pathway.html

KEGG Metabolic Pathways with PRIAM

KEGG Metabolic Pathways with PRIAM Graphical pathway maps. Link to PRIAM ... C5-Branched dibasic acid metabolism · Inositol metabolism · Energy Metabolism ...
genome.ornl.gov/microbial/ rsph/combined/RES_PRIAM/index.html - 13k -

Metabolism

Carbohydrate Metabolism
	Glycolysis / Gluconeogenesis
	Citrate cycle (TCA cycle)
	Pentose phosphate pathway
	Pentose and glucuronate interconversions
	Fructose and mannose metabolism
	Galactose metabolism
	Ascorbate and aldarate metabolism
	Pyruvate metabolism
	Glyoxylate and dicarboxylate metabolism
	Propanoate metabolism
	Butanoate metabolism
	C5-Branched dibasic acid metabolism
	Inositol metabolism
Energy Metabolism
	Oxidative phosphorylation
	ATP synthesis
	Photosynthesis
	Carbon fixation
	Reductive carboxylate cycle (CO2 fixation)
	Methane metabolism
	Nitrogen metabolism
	Sulfur metabolism
Lipid Metabolism
	Fatty acid biosynthesis (path 1)
	Fatty acid biosynthesis (path 2)
	Fatty acid metabolism
	Synthesis and degradation of ketone bodies
	Sterol biosynthesis
	Bile acid biosynthesis
	C21-Steroid hormone metabolism
	Androgen and estrogen metabolism
Nucleotide Metabolism
	Purine metabolism
	Pyrimidine metabolism
	Nucleotide sugars metabolism
Amino Acid Metabolism
	Glutamate metabolism
	Alanine and aspartate metabolism
	Glycine, serine and threonine metabolism
	Methionine metabolism
	Cysteine metabolism
	Valine, leucine and isoleucine degradation
	Valine, leucine and isoleucine biosynthesis
	Lysine biosynthesis
	Lysine degradation
	Arginine and proline metabolism
	Histidine metabolism
	Tyrosine metabolism
	Phenylalanine metabolism
	Tryptophan metabolism
	Phenylalanine, tyrosine and tryptophan biosynthesis
	Urea cycle and metabolism of amino groups
Metabolism of Other Amino Acids
	beta-Alanine metabolism
	Taurine and hypotaurine metabolism
	Aminophosphonate metabolism
	Selenoamino acid metabolism
	Cyanoamino acid metabolism
	D-Glutamine and D-glutamate metabolism
	D-Arginine and D-ornithine metabolism
	D-Alanine metabolism
	Glutathione metabolism
Metabolism of Complex Carbohydrates
	Starch and sucrose metabolism
	N-Glycans biosynthesis
	O-Glycans biosynthesis
	N-Glycan degradation
	Aminosugars metabolism
	Lipopolysaccharide biosynthesis
	Peptidoglycan biosynthesis
	Glycosaminoglycan degradation
	Chondroitin / heparan sulfate biosynthesis
	Keratan sulfate biosynthesis
Metabolism of Complex Lipids
	Glycerolipid metabolism
	Inositol phosphate metabolism
	Sphingophospholipid biosynthesis
	Phospholipid degradation
	Sphingoglycolipid metabolism
	Blood group glycolipid biosynthesis - lactoseries
	Blood group glycolipid biosynthesis - neo-lactoseries
	Globoside metabolism
	Ganglioside biosynthesis
	Prostaglandin and leukotriene metabolism
Metabolism of Cofactors and Vitamins
	Thiamine metabolism
	Riboflavin metabolism
	Vitamin B6 metabolism
	Nicotinate and nicotinamide metabolism
	Pantothenate and CoA biosynthesis
	Biotin metabolism
	Folate biosynthesis
	One carbon pool by folate
	Retinol metabolism
	Porphyrin and chlorophyll metabolism
	Ubiquinone biosynthesis
Biosynthesis of Secondary Metabolites
	Terpenoid biosynthesis
	Indole and ipecac alkaloid biosynthesis
	Flavonoids, stilbene and lignin biosynthesis
	Alkaloid biosynthesis I
	Alkaloid biosynthesis II
	Penicillins and cephalosporins biosynthesis
	beta-Lactam resistance
	Streptomycin biosynthesis
	Erythromycin biosynthesis
	Tetracycline biosynthesis
	Clavulanic acid biosynthesis
	Puromycin biosynthesis
Biodegradation of Xenobiotics
	Caprolactam degradation
	Biphenyl degradation
	Toluene and xylene degradation
	gamma-Hexachlorocyclohexane degradation
	3-Chloroacrylic acid degradation
	1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation
	2,4-Dichlorobenzoate degradation
	1,2-Dichloroethane degradation
	Tetrachloroethene degradation
	Styrene degradation
	1,4-Dichlorobenzene degradation
	Nitrobenzene degradation
	Ethylbenzene degradation
	Fluorene degradation
	Carbazole degradation
	Benzoate degradation via CoA ligation
	Benzoate degradation via hydroxylation
	Atrazine degradation

KEGG metabolic pathways


Carbohydrate Metabolism
	map00010	[ xml \| html \| graphics ]	May 09, 2006	Glycolysis / Gluconeogenesis
	map00020	[ xml \| html \| graphics ]	May 02, 2006	Citrate cycle (TCA cycle)
	map00030	[ xml \| html \| graphics ]	Jun 09, 2006	Pentose phosphate pathway
	map00040	[ xml \| html \| graphics ]	Jun 10, 2006	Pentose and glucuronate interconversions
	map00051	[ xml \| html \| graphics ]	Jun 10, 2006	Fructose and mannose metabolism
	map00052	[ xml \| html \| graphics ]	Jun 09, 2006	Galactose metabolism
	map00053	[ xml \| html \| graphics ]	Jun 10, 2006	Ascorbate and aldarate metabolism
	map00500	[ xml \| html \| graphics ]	May 10, 2006	Starch and sucrose metabolism
	map00530	[ xml \| html \| graphics ]	May 10, 2006	Aminosugars metabolism
	map00520	[ xml \| html \| graphics ]	Jun 10, 2006	Nucleotide sugars metabolism
	map00620	[ xml \| html \| graphics ]	Jun 09, 2006	Pyruvate metabolism
	map00630	[ xml \| html \| graphics ]	Jun 09, 2006	Glyoxylate and dicarboxylate metabolism
	map00640	[ xml \| html \| graphics ]	Jun 09, 2006	Propanoate metabolism
	map00650	[ xml \| html \| graphics ]	Jun 10, 2006	Butanoate metabolism
	map00660	[ xml \| html \| graphics ]	Jun 09, 2005	C5-Branched dibasic acid metabolism
	map00031	[ xml \| html \| graphics ]	Jun 09, 2006	Inositol metabolism
	map00562	[ xml \| html \| graphics ]	Jun 09, 2006	Inositol phosphate metabolism

Energy Metabolism
	map00190	[ xml \| html \| graphics ]	Jun 06, 2006	Oxidative phosphorylation
	map00193	[ xml \| html \| graphics ]	Nov 19, 2004	ATP synthesis
	map00195	[ xml \| html \| graphics ]	Nov 01, 2005	Photosynthesis
	map00710	[ xml \| html \| graphics ]	Jun 02, 2006	Carbon fixation
	map00720	[ xml \| html \| graphics ]	Jun 09, 2005	Reductive carboxylate cycle (CO2 fixation)
	map00680	[ xml \| html \| graphics ]	Apr 29, 2006	Methane metabolism
	map00910	[ xml \| html \| graphics ]	May 25, 2006	Nitrogen metabolism
	map00920	[ xml \| html \| graphics ]	Apr 29, 2006	Sulfur metabolism

Lipid Metabolism
	map00061	[ xml \| html \| graphics ]	Jun 02, 2006	Fatty acid biosynthesis
	map00062	[ xml \| html \| graphics ]	Oct 07, 2005	Fatty acid elongation in mitochondria
	map00071	[ xml \| html \| graphics ]	Jun 10, 2006	Fatty acid metabolism
	map00072	[ xml \| html \| graphics ]	Jun 09, 2005	Synthesis and degradation of ketone bodies
	map00100	[ xml \| html \| graphics ]	Jun 09, 2006	Biosynthesis of steroids
	map00120	[ xml \| html \| graphics ]	Apr 20, 2006	Bile acid biosynthesis
	map00140	[ xml \| html \| graphics ]	Jun 10, 2006	C21-Steroid hormone metabolism
	map00150	[ xml \| html \| graphics ]	Jun 10, 2006	Androgen and estrogen metabolism
	map00561	[ xml \| html \| graphics ]	Jun 09, 2006	Glycerolipid metabolism
	map00564	[ xml \| html \| graphics ]	Jun 01, 2006	Glycerophospholipid metabolism
	map00590	[ xml \| html \| graphics ]	May 19, 2006	Arachidonic acid metabolism
	map00591	[ xml \| html \| graphics ]	Feb 03, 2006	Linoleic acid metabolism

Nucleotide Metabolism
	map00230	[ xml \| html \| graphics ]	Jun 10, 2006	Purine metabolism
	map00240	[ xml \| html \| graphics ]	May 09, 2006	Pyrimidine metabolism

Amino Acid Metabolism
	map00251	[ xml \| html \| graphics ]	Nov 01, 2005	Glutamate metabolism
	map00252	[ xml \| html \| graphics ]	Jun 09, 2005	Alanine and aspartate metabolism
	map00260	[ xml \| html \| graphics ]	May 09, 2006	Glycine, serine and threonine metabolism
	map00271	[ xml \| html \| graphics ]	Jun 01, 2006	Methionine metabolism
	map00272	[ xml \| html \| graphics ]	Nov 01, 2005	Cysteine metabolism
	map00280	[ xml \| html \| graphics ]	May 02, 2006	Valine, leucine and isoleucine degradation
	map00290	[ xml \| html \| graphics ]	Nov 01, 2005	Valine, leucine and isoleucine biosynthesis
	map00300	[ xml \| html \| graphics ]	Nov 01, 2005	Lysine biosynthesis
	map00310	[ xml \| html \| graphics ]	May 08, 2006	Lysine degradation
	map00330	[ xml \| html \| graphics ]	Apr 25, 2006	Arginine and proline metabolism
	map00340	[ xml \| html \| graphics ]	May 09, 2006	Histidine metabolism
	map00350	[ xml \| html \| graphics ]	Jun 02, 2006	Tyrosine metabolism
	map00360	[ xml \| html \| graphics ]	May 08, 2006	Phenylalanine metabolism
	map00380	[ xml \| html \| graphics ]	Jun 09, 2006	Tryptophan metabolism
	map00400	[ xml \| html \| graphics ]	Mar 23, 2006	Phenylalanine, tyrosine and tryptophan biosynthesis
	map00220	[ xml \| html \| graphics ]	Jun 09, 2005	Urea cycle and metabolism of amino groups

Metabolism of Other Amino Acids
	map00410	[ xml \| html \| graphics ]	Oct 06, 2005	beta-Alanine metabolism
	map00430	[ xml \| html \| graphics ]	Nov 01, 2005	Taurine and hypotaurine metabolism
	map00440	[ xml \| html \| graphics ]	May 10, 2006	Aminophosphonate metabolism
	map00450	[ xml \| html \| graphics ]	Apr 29, 2006	Selenoamino acid metabolism
	map00460	[ xml \| html \| graphics ]	May 09, 2006	Cyanoamino acid metabolism
	map00471	[ xml \| html \| graphics ]	Jun 09, 2005	D-Glutamine and D-glutamate metabolism
	map00472	[ xml \| html \| graphics ]	Jun 09, 2005	D-Arginine and D-ornithine metabolism
	map00473	[ xml \| html \| graphics ]	Jun 09, 2005	D-Alanine metabolism
	map00480	[ xml \| html \| graphics ]	Jun 09, 2005	Glutathione metabolism

Glycan Biosynthesis and Metabolism
	map00510	[ xml \| html \| graphics ]	May 30, 2006	N-Glycan biosynthesis
	map00512	[ xml \| html \| graphics ]	May 11, 2006	O-Glycan biosynthesis
	map00532	[ xml \| html \| graphics ]	Apr 13, 2006	Chondroitin sulfate biosynthesis
	map00534	[ xml \| html \| graphics ]	Apr 13, 2006	Heparan sulfate biosynthesis
	map00531	[ xml \| html \| graphics ]	Apr 10, 2006	Glycosaminoglycan degradation
	map00540	[ xml \| html \| graphics ]	May 12, 2006	Lipopolysaccharide biosynthesis
	map00550	[ xml \| html \| graphics ]	May 09, 2006	Peptidoglycan biosynthesis
	map00563h	[ xml \| html \| graphics ]	Apr 13, 2006	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
	map00563y	[ xml \| html \| graphics ]	Apr 13, 2006	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
	map00600	[ xml \| html \| graphics ]	May 31, 2006	Glycosphingolipid metabolism
	map00601	[ xml \| html \| graphics ]	Apr 13, 2006	Blood group glycolipid biosynthesis - lactoseries
	map00602	[ xml \| html \| graphics ]	May 15, 2006	Blood group glycolipid biosynthesis - neo-lactoseries
	map00603	[ xml \| html \| graphics ]	May 15, 2006	Globoside metabolism
	map00604	[ xml \| html \| graphics ]	May 15, 2006	Ganglioside biosynthesis

Biosynthesis of Polyketides and Nonribosomal Peptides
	map00522	[ xml \| html \| graphics ]	Dec 14, 2005	Biosynthesis of 12-, 14- and 16-membered macrolides
	map01051	[ xml \| html \| graphics ]	May 09, 2006	Biosynthesis of ansamycins
	map01056	[ xml \| html \| graphics ]	Nov 01, 2005	Biosynthesis of type II polyketide backbone
	map01057	[ xml \| html \| graphics ]	Nov 01, 2005	Biosynthesis of type II polyketide products
	map00523	[ xml \| html \| graphics ]	Jun 10, 2006	Polyketide sugar unit biosynthesis
	map01053	[ xml \| html \| graphics ]	Nov 01, 2005	Biosynthesis of siderophore group nonribosomal peptides
	map01055	[ xml \| html \| graphics ]	Jun 09, 2005	Biosynthesis of vancomycin group antibiotics

Metabolism of Cofactors and Vitamins
	map00730	[ xml \| html \| graphics ]	Nov 01, 2005	Thiamine metabolism
	map00740	[ xml \| html \| graphics ]	Nov 01, 2005	Riboflavin metabolism
	map00750	[ xml \| html \| graphics ]	Jun 09, 2006	Vitamin B6 metabolism
	map00760	[ xml \| html \| graphics ]	Nov 01, 2005	Nicotinate and nicotinamide metabolism
	map00770	[ xml \| html \| graphics ]	Jun 10, 2006	Pantothenate and CoA biosynthesis
	map00780	[ xml \| html \| graphics ]	Nov 01, 2005	Biotin metabolism
	map00790	[ xml \| html \| graphics ]	May 30, 2006	Folate biosynthesis
	map00670	[ xml \| html \| graphics ]	Nov 01, 2005	One carbon pool by folate
	map00830	[ xml \| html \| graphics ]	Jun 09, 2006	Retinol metabolism
	map00860	[ xml \| html \| graphics ]	Mar 03, 2006	Porphyrin and chlorophyll metabolism
	map00130	[ xml \| html \| graphics ]	Dec 03, 2005	Ubiquinone biosynthesis

Biosynthesis of Secondary Metabolites
	map00900	[ xml \| html \| graphics ]	Jun 21, 2005	Terpenoid biosynthesis
	map00902	[ xml \| html \| graphics ]	Jun 09, 2005	Monoterpenoid biosynthesis
	map00903	[ xml \| html \| graphics ]	May 02, 2006	Limonene and pinene degradation
	map00904	[ xml \| html \| graphics ]	May 09, 2006	Diterpenoid biosynthesis
	map00901	[ xml \| html \| graphics ]	Dec 06, 2005	Indole and ipecac alkaloid biosynthesis
	map00940	[ xml \| html \| graphics ]	May 09, 2006	Stilbene, coumarine and lignin biosynthesis
	map00941	[ xml \| html \| graphics ]	Jun 02, 2006	Flavonoid biosynthesis
	map00950	[ xml \| html \| graphics ]	Nov 01, 2005	Alkaloid biosynthesis I
	map00960	[ xml \| html \| graphics ]	Dec 01, 2005	Alkaloid biosynthesis II
	map00311	[ xml \| html \| graphics ]	Mar 29, 2006	Penicillins and cephalosporins biosynthesis
	map00521	[ xml \| html \| graphics ]	Jun 10, 2006	Streptomycin biosynthesis
	map00253	[ xml \| html \| graphics ]	Dec 06, 2005	Tetracycline biosynthesis
	map00331	[ xml \| html \| graphics ]	May 09, 2006	Clavulanic acid biosynthesis
	map00231	[ xml \| html \| graphics ]	Jun 09, 2005	Puromycin biosynthesis
	map00401	[ xml \| html \| graphics ]	Jul 01, 2005	Novobiocin biosynthesis

Xenobiotics Biodegradation and Metabolism
	map00930	[ xml \| html \| graphics ]	May 10, 2006	Caprolactam degradation
	map00621	[ xml \| html \| graphics ]	May 09, 2006	Biphenyl degradation
	map00622	[ xml \| html \| graphics ]	Dec 06, 2005	Toluene and xylene degradation
	map00361	[ xml \| html \| graphics ]	May 30, 2006	gamma-Hexachlorocyclohexane degradation
	map00641	[ xml \| html \| graphics ]	Dec 06, 2005	3-Chloroacrylic acid degradation
	map00351	[ xml \| html \| graphics ]	Dec 03, 2005	1,1,1-Trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) degradation
	map00623	[ xml \| html \| graphics ]	Dec 03, 2005	2,4-Dichlorobenzoate degradation
	map00631	[ xml \| html \| graphics ]	Jun 09, 2005	1,2-Dichloroethane degradation
	map00625	[ xml \| html \| graphics ]	Dec 03, 2005	Tetrachloroethene degradation
	map00643	[ xml \| html \| graphics ]	Dec 06, 2005	Styrene degradation
	map00627	[ xml \| html \| graphics ]	Dec 22, 2005	1,4-Dichlorobenzene degradation
	map00626	[ xml \| html \| graphics ]	Dec 03, 2005	Nitrobenzene degradation
	map00642	[ xml \| html \| graphics ]	May 02, 2006	Ethylbenzene degradation
	map00628	[ xml \| html \| graphics ]	Dec 03, 2005	Fluorene degradation
	map00629	[ xml \| html \| graphics ]	Dec 06, 2005	Carbazole degradation
	map00632	[ xml \| html \| graphics ]	May 08, 2006	Benzoate degradation via CoA ligation
	map00362	[ xml \| html \| graphics ]	Dec 06, 2005	Benzoate degradation via hydroxylation
	map00791	[ xml \| html \| graphics ]	Nov 01, 2005	Atrazine degradation
	map00363	[ xml \| html \| graphics ]	Nov 01, 2005	Bisphenol A degradation
	map00624	[ xml \| html \| graphics ]	May 08, 2006	1- and 2-Methylnaphthalene degradation
	map00980	[ xml \| html \| graphics ]	Feb 03, 2006	Metabolism of xenobiotics by cytochrome P450